Endocrine Abstracts

Introduction: Hypopituitary patients receiving conventional hormone replacement, but without GH replacement, have an increased mortality from cardiovascular diseases. Inadequate hormone replacement is a possible cause of this increased mortality. GH deficiency in adult patients has been associated with several cardiovascular risk factors, including hyperlipidemia, increased abdominal adiposity, and impaired insulin sensitivity.The aim of the study is an ...

Introduction: Adiponectin (AdipoQ) is a known insulinsensitizing adipokine which is also present in fetal circulation. It has been postulated to play a role in the regulation of fetal growth and development together with other adipokines. The aim of the study was to determine fetal adiponectin and find its correlations with the neonatal birthweight and maternal AdipoQ.Patients and methods: The study included 36 women with singleton pregnancy (20 diagnose...

Introduction: The course of type 2 diabetes (DM2) is linked with increased fibroblast growth factor 21 (FGF21) concentrations, however little information is available on the prognostic significance of FGF21 in DM2. The aim of the study was to assess whether FGF21 may be a predictor of cardiovascular (CV) events in patients with DM2.Patients and methods: The study comprised 87 patients with DM2, aged 57–66 years, with the median duration of diabetes ...

Fibroblast growth factor-21 (FGF-21) is a novel adipocytokine, which is believed to be involved in improvement of insulin sensitivity and pathogenesis of type 2 diabetes.The aim of the study was comparative assessment of FGF-21 concentrations in serum of patients with type 2 diabetes and evaluation of possible relationships between the studied cytokine and selected clinical and biochemical parameters.Forty-four patients with type 2...

Little is known about the prevalence and significance of islet cell immunity in elderly patients with type 2 diabetes. The low antibody titers against islet-cell antigens in LADA elderly patients may be a sign of a less aggressive autoimmune diabetes.The objective: To establish the changing frequency and titers of GADA and IAA in elderly diabetics.Material: 83(56F;27M)diabetic patients (60–91 y) divided in age related groups. ...

Introduction: Adiponectin shows its beneficial insulin-sensitizing properties, however, women with gestational diabetes mellitus (GDM) present hypoadiponectinemia.Aim of the study: To assess the expression of adiponectin gene as well as its AdipoR1 and AdipoR2 receptors in placenta and adipose tissue and to determine potential correlations with chosen metabolic parameters (clinical and biochemical).Patients and methods: Thirty-six ...

Introduction: The patients with ACS and scheduled for an elective coronary angiography have high frequency of both newly and previously diagnosed diabetes. The diabetic patients with acute myocardial infarction have an increased risk of death. Elevated blood HYC is strongly related to an increased risk for atherosclerosis and cardiovascular disease. This association is particularly evident in patients with diabetes.Aim of the study: An attempt to evaluat...